From: preecej <preecej@localhost>
Date: Tue, 25 Mar 2014 00:00:54 +0000 (+0000)
Subject: wip: uniprot substitution for ref loci
X-Git-Url: http://gitweb.planteome.org/?a=commitdiff_plain;h=0f8532046d0501c40199bb2c34f7b85123cb82e1;p=old-jaiswallab-svn%2F.git

wip: uniprot substitution for ref loci

svn path=/; revision=560
---

diff --git a/Personnel/preecej/python_singletons/incomparanoid.py b/Personnel/preecej/python_singletons/incomparanoid.py
index 7bf3969..6a6f231 100755
--- a/Personnel/preecej/python_singletons/incomparanoid.py
+++ b/Personnel/preecej/python_singletons/incomparanoid.py
@@ -15,6 +15,7 @@ import re
 # globals
 #----------------------------------------------------------------------------------------------------------------------
 list_stats = []
+dict_uniprot_map = {}
 dict_ens_map = {}
 dict_inp_map = {}
 
@@ -46,7 +47,18 @@ class switch(object):
 #----------------------------------------------------------------------------------------------------------------------
 
 #----------------------------------------------------------------------------------------------------------------------
-def create_inp_map(inparanoid_input_path) :
+def create_dict_uniprot_map() :
+#----------------------------------------------------------------------------------------------------------------------
+    """
+    create reference-to-uniprot mapping dictionary
+    """
+    dict_uniprot_map = {} # local
+    # read map file, populate dict (note possibility of one uniprot id to many ref loci)
+    
+    return dict_uniprot_map
+
+#----------------------------------------------------------------------------------------------------------------------
+def create_inp_map(inparanoid_input_path, uniprot_substitution, dict_uniprot_map) :
 #----------------------------------------------------------------------------------------------------------------------
     """
     open the inparanoid file (which is already loci-filtered for curated reference set) and generate a 2-col mapping of PRJ to LOC loci
@@ -80,7 +92,7 @@ def create_inp_map(inparanoid_input_path) :
 
 
 #----------------------------------------------------------------------------------------------------------------------
-def create_ens_map(filtering_loci_path, ensembl_input_path, rap_map_path, recip_id) :
+def create_ens_map(filtering_loci_path, ensembl_input_path, rap_map_path, recip_id, uniprot_substitution, dict_uniprot_map) :
 #----------------------------------------------------------------------------------------------------------------------
     """
     open the ensemble plants and rap::irgsp mapping files and generate a hash mapping of reference to projected loci where 
@@ -159,7 +171,7 @@ def compare_maps(dict_ens_map, dict_inp_map, comparison_file_path, ensembl_outpu
     ref_dict = {}
     set_ens_os_loci = set()
     set_inp_os_loci = set()
-
+    
     #ref_dict structure: {os locus : [[ens projected locus, ...], [inp projected locus, ...], # of common loci]}
 
     # iterate over both map files and build an overlap map, counting inclusions and exclusions at the reference and projection level
@@ -227,7 +239,7 @@ def compare_maps(dict_ens_map, dict_inp_map, comparison_file_path, ensembl_outpu
     INP_OUT_FILE = open(inparanoid_output_path,'w')
     INP_FLAT_OUT_FILE = open(inparanoid_output_path + ".flat",'w')
     for k, v in sorted(dict_inp_map.iteritems()) :
-        INP_OUT_FILE.write(k + "\t" + ",".join(v) + "\n")
+        INP_OUT_FILE.write(k + "\t" + " ".join(v) + "\n")
         for projection in sorted(v) :
             INP_FLAT_OUT_FILE.write(k + "\t" + projection + "\n")
     INP_OUT_FILE.close()
@@ -236,7 +248,7 @@ def compare_maps(dict_ens_map, dict_inp_map, comparison_file_path, ensembl_outpu
     ENS_OUT_FILE = open(ensembl_output_path,'w')
     ENS_FLAT_OUT_FILE = open(ensembl_output_path + ".flat",'w')
     for k, v in sorted(dict_ens_map.iteritems()) :
-        ENS_OUT_FILE.write(k + "\t" + ",".join(v) + "\n")
+        ENS_OUT_FILE.write(k + "\t" + " ".join(v) + "\n")
         for projection in sorted(v) :
             ENS_FLAT_OUT_FILE.write(k + "\t" + projection + "\n")
     ENS_OUT_FILE.close()
@@ -258,6 +270,7 @@ parser.add_argument('-r', '--reciprocal_id', type=int, help='reciprocal identity
 # TODO: add an "inparanoid super-cluster vs. conventional input" flag
 
 # output settings
+parser.add_argument('-u', '--uniprot_substitution', help='substitute UniProt for reference loci', action='store_true')
 parser.add_argument('-c', '--comparison_file_path', help='output file containing statistical comparisons')
 parser.add_argument('-E', '--ensembl_output_path', help='output file containing flat (1-to-many) ensemble ortho pairs')
 parser.add_argument('-I', '--inparanoid_output_path', help='output file containing flat (1-to-many) inparanoid ortho pairs')
@@ -265,9 +278,13 @@ parser.add_argument('-I', '--inparanoid_output_path', help='output file containi
 args = parser.parse_args()
 #print args
 
+# create ref loci::UniProt map, if specified
+if args.uniprot_substitution :
+    dict_uniprot_map = create_dict_uniprot_map()
+
 # create projection maps
-dict_inp_map = create_inp_map(args.inparanoid_input_path)
-dict_ens_map = create_ens_map(args.filtering_loci_path, args.ensembl_input_path, args.rap_map_path, args.reciprocal_id)
+dict_inp_map = create_inp_map(args.inparanoid_input_path, args.uniprot_substitution, dict_uniprot_map)
+dict_ens_map = create_ens_map(args.filtering_loci_path, args.ensembl_input_path, args.rap_map_path, args.reciprocal_id, args.uniprot_substitution, dict_uniprot_map)
 
 # generate stats and output them
 compare_maps(dict_ens_map, dict_inp_map, args.comparison_file_path, args.ensembl_output_path, args.inparanoid_output_path)